Advances in medical research, the consumer empowerment, and rising cost of health care have demonstrated the need to treatment models that are holistic and client driven. Complementary and alternative medicine (CAM) offers consumers choices. It includes traditional healing practices, medical systems that are thousands of years old and new or innovative treatments that may be consider unconventional. Well known examples of CAM include herbal remedies, mindfulness, meditation, manipulative/movement therapies, and Chinese Medicine. Knowledge of CAM offers social workers in all settings the opportunity to provide education and advocacy in seeking client centered and culturally competent treatment options.

Sunday, April 24, 2011

Psychoneuroimmunolgy and Schizophrenia

Is there a connection between the immune system and psychiatric disorders?  Researchers in the field of psychoneuroimmunolgy have been able to determine that infections, which affect the immune system, have been linked to psychiatric disorders.  The immune system and the central nervous system (CNS) share the mechanisms of communication including chemical and electrical components known as neurotransmitters, neuropeptides, and cytokines.  Disregulation of the immune system is believed to contribute to the development of psychiatric disorders (Daruna, 2004).  Stress, infections, pathogens, toxins and other environmental factors are known to activate the immune system.   Some researchers believe that activation of certain immune system cells in response to an infection or on a chronic condition contributes to mental illness in different ways (Daruna).  Cytokines are small cell-signaling molecules that have been classified as proteins, peptides, or glycoproteins that are secreted by the innate and acquired immune systems.  They exert different effects on the targeted cell which can include inflammation, increase body temperature, respond to specific antigens and are responsible for growth and differentiation of cells within the immune system (Daruna).  Depression and distress enhance the production of proinflammatory cytokines.  Research suggests that there is a strong correlation between the immune system and the pathophysiology of schizophrenia (Strous & Shoenfeld, 2007).  Studies have demonstrated that patients with schizophrenia have non-specific over activation of the immunological response system, including T-helper cells, both Type 1 and Type 2 in the adaptive immune system (Steiner, 2010).  Type 1 T-helper cells promote the activation pro-inflammatory response.  Schizophrenic patients have also been found to have increased levels of cytokines, macrophages and lymphocytes in peripheral blood and bone marrow.  First psychotic break has been linked with immune system disregulation.  Researchers hypothesize that rapid changes occurring during adolescent brain development may trigger the activation of latent viruses or genes that create an immune response leading to the symptoms of first psychotic break (Daruna).  Patients with schizophrenia have demonstrated signs of neurodegeneration with progressive cortical atrophy.  Post-mortem analyses have confirmed the formation of lesions in the grey matter as well as elevated levels of the basic proteins that cause degeneration to human myelin.  Researchers have noted an increase incidence of schizophrenia with individuals born in the winter and in northern latitudes (Daruna).  Other studies suggest that in utero infections may be an underlying cause of schizophrenia (Meyer & Feldon, 2009).  Greater immunological disregulation is attributed to increased risk for the onset and acuity of schizophrenia (Daruna). 

Daruna, J. H.  (2004).  Introduction to Psychoneuroimmunology. Boston:  Elsevier Academic Press.
Meyer, U., & Feldon, J. (2009). Neural basis of psychosis-related behaviour in the infection model of schizophrenia. Behavioural Brain Research, 204(2), 322-334. doi:10.1016/j.bbr.2008.12.022
Steiner, J., Jacobs, R., Panteli, B., Brauner, M., Schiltz, K., Bahn, S., & ... Bogerts, B. (2010). Acute schizophrenia is accompanied by reduced T cell and increased B cell immunity. European Archives of Psychiatry & Clinical Neuroscience, 260(7), 509-518. doi:10.1007/s00406-010-0098-x
Strous, R. D., & Shoenfeld, Y. (2006). Schizophrenia, autoimmunity and immune system dysregulation: A comprehensive model updated and revisited. Journal of Autoimmunity, 27(2), 71-80. doi: 10.1016/j.jaut.2006.07.006


  1. Schizophrenia research seems to be quite popular. There are many studies that look promising to uncover causes and potential remedies for schizophrenia. This past April 2011, the International Congress on Schizophrenia Research (ICOSR), was held. They looked at gene expression, neurotransmitters, visual process deficits, cognition and countless other patterns. This is exciting to see many different disciplines trying to show links between their studies and schizophrenia. One study at ICOSR that was regarding cognitive enhancement therapy(CET) showing promise as a treatment strategy in improving social cognition and functioning. This would be an alternative to a study showing great promise using a cholinergic drug called modafinil, a drug approved by the FDA for the treatment of narcolepsy. In the double blind study researchers used modafinil as an adjunct with typical and atypical anti-psychotics. Modafinil was found to improve sustained attention (digit span-backwards), spatial working memory, and inhibition control.

  2. My son was victim of a mental intriguing disorder called Schizophrenia unable to distinguish between fantasy and reality.And I have looked for solution, gave him Seroquel, Zyprexa and many medication but they were all worsened the situation, All hope was lost before I met a man who directed me to where I got my medication.It is a herbal medication, It is a really good for schizophrenia treatment, It is better than those I have been using over the years, If you having such problem for advice and necessary solution, contact me , so I can direct you to where you can get better solution (